You can take allopurinol at whatever time of day you find easiest to remember; however try to take your doses at the same time of day each day, as this will help you to take it regularly. If you forget to take a dose, take it as soon as you remember. How to use Allopurinol. Take this medication by mouth, usually once daily or as directed by your doctor. Take this medication after a meal to reduce stomach upset. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. You may take this medicine after meals to avoid stomach upset. Take this medicine with plenty of liquids to help prevent kidney stones. Check with your doctor about the amount of liquid you should drink each day. You should also. You should take each dose of allopurinol with a full glass of water. To reduce the risk of kidney stones forming, you should drink eight to 10 full glasses of fluid every day. Actually, there is no mandatory time for the intake of allopurinol. This is since the medicine is suggested in gout to reduce the levels of uric acid. As a matter of fact, patients are recommended to take each medicine dosage with a glass full of water. This is in order to reduce the risk of the kidney stone formation. Furthermore, drinking 8-10 glasses of water each and every day is highly. Take each dose with a full glass of water. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise. Anytime. Take the drug once daily after a meal and with plenty of water. I would just be consistent and take it every day around the same time. Take with food if allopurinol upsets your stomach. You may have gout attacks more often when you first start taking allopurinol. Your doctor may recommend other gout medication to take at this time. This can take some months and you may have more attacks of gout during this time. This is more likely if your urate levels are very high or you've had gout for a long time. It doesn't mean the drug isn't working. Attacks of gout usually stop within a year as long as your urate level has lowered sufficiently.